Eawag, the Swiss Federal Institute of Aquatic Science and Technology, is a Swiss-based and internationally networked aquatic research institute within the ETH domain (Swiss Federal Institute of Science and Technology). It is committed to the ecologically, economically and socially responsible management of water resources and aquatic ecosystems.
Within the EU project EDA-EMERGE the Department of Environmental Toxicology seeks a
PhD in the field of BIOCHEMICAL ECOTOXICOLOGY
EDA-EMERGE aims at training a new generation of young scientists in the interdisciplinary techniques required to meet the major challenges in the monitoring, assessment and management of toxic pollution in European river basins, taking into account the enormous complexity of contamination, effects and cause-effect relationships. By integrating innovative mode-of-action based biodiagnostic tools including in vitro tests, transgenic organisms and “omics” techniques with powerful fractionation and cutting edge analytical and computational structure elucidation tools, a new generation of effect directed analysis approaches will be developed for the identification of toxicants in European surface and drinking waters.
Because in vivo models represent a higher level of organization than in vitro assays, we will use the zebrafish as model organism and apply proteomic techniques to analyze and better understand adverse effects of model chemicals and environmental samples, found to cause effects in in vitro assays, on this organism. In vivo models cover non-genomic effects and cross-talk between signaling pathways and all processes needed for homeostasis, growth, reproduction and stress response. This approach will allow us to identify protein markers that are linked to specific modes of toxic action. It will also be used to complement results obtained with DNA microarrays by partners of the EDA-EMERGE consortium and to compare in vivo and in vitro readouts. The model compounds used will be known to interact with the hypothalamic-pituitary- adrenal axis (HPA), a major part of the endocrine system that controls reactions to stress and regulates many processes, including immune response and reproduction, and as such is a prime target of xenobiotics.
If you are excited about advancing knowledge in linking mode-of-action based biodiagnostic tools, specifically proteomics techniques, with cutting edge analytical tools and joining an interdisciplinary research team, you are invited to apply. Your background should be in biochemistry or analytical chemistry. Excellent communication skills in English and skills in team work are essential. The position is available immediately. We offer a stimulating research environment in a lively and social institute in Dübendorf near Zürich, Switzerland.
Salary will be in accordance with Marie Curie rules of the European Commission. Besides a full employment contract, including social security, the candidate will receive mobility allowances. Note the mobility restrictions outlined by the EC: Researchers can be of any nationality but at the time of recruitment by the host organization, researchers must not have resided or carried out their main activity (work, studies, etc) in the country of their host organization for more than 12months in the 3 years immediately prior to the reference date. Applicants must also be in the first four years (date of MSc certificate or equivalent) of their research careers.
Applications should include a brief statement describing your motivation to apply, curriculum vitae, copies of your academic qualifications and the names (with e-mail addresses) of two potential referees.
Please submit your application by January 31st 2012. For further information, consult http://www.eawag.ch/ or contact Prof. Kristin Schirmer kristin.schirmer@eawag.ch or Dr. Marc Suter, marc.suter@eawag.ch.
We look forward to receive your application.
The quickest way is to apply online. Please click on the button below. This will take you directly to the application form.
For Further Information
Within the EU project EDA-EMERGE the Department of Environmental Toxicology seeks a
PhD in the field of BIOCHEMICAL ECOTOXICOLOGY
EDA-EMERGE aims at training a new generation of young scientists in the interdisciplinary techniques required to meet the major challenges in the monitoring, assessment and management of toxic pollution in European river basins, taking into account the enormous complexity of contamination, effects and cause-effect relationships. By integrating innovative mode-of-action based biodiagnostic tools including in vitro tests, transgenic organisms and “omics” techniques with powerful fractionation and cutting edge analytical and computational structure elucidation tools, a new generation of effect directed analysis approaches will be developed for the identification of toxicants in European surface and drinking waters.
Because in vivo models represent a higher level of organization than in vitro assays, we will use the zebrafish as model organism and apply proteomic techniques to analyze and better understand adverse effects of model chemicals and environmental samples, found to cause effects in in vitro assays, on this organism. In vivo models cover non-genomic effects and cross-talk between signaling pathways and all processes needed for homeostasis, growth, reproduction and stress response. This approach will allow us to identify protein markers that are linked to specific modes of toxic action. It will also be used to complement results obtained with DNA microarrays by partners of the EDA-EMERGE consortium and to compare in vivo and in vitro readouts. The model compounds used will be known to interact with the hypothalamic-pituitary- adrenal axis (HPA), a major part of the endocrine system that controls reactions to stress and regulates many processes, including immune response and reproduction, and as such is a prime target of xenobiotics.
If you are excited about advancing knowledge in linking mode-of-action based biodiagnostic tools, specifically proteomics techniques, with cutting edge analytical tools and joining an interdisciplinary research team, you are invited to apply. Your background should be in biochemistry or analytical chemistry. Excellent communication skills in English and skills in team work are essential. The position is available immediately. We offer a stimulating research environment in a lively and social institute in Dübendorf near Zürich, Switzerland.
Applications should include a brief statement describing your motivation to apply, curriculum vitae, copies of your academic qualifications and the names (with e-mail addresses) of two potential referees.
Please submit your application by January 31st 2012. For further information, consult http://www.eawag.ch/ or contact Prof. Kristin Schirmer kristin.schirmer@eawag.ch or Dr. Marc Suter, marc.suter@eawag.ch.
We look forward to receive your application.
The quickest way is to apply online. Please click on the button below. This will take you directly to the application form.
For Further Information
