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Postdoctoral Fellowship in Molecular Biology - Germany

A postdoctoral position studying the molecular mechanisms of cellular and retroviral mRNA decay is immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Laboratory description : The laboratory is an RNA biochemistry and molecular biology research group established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The research of the group and its members is supported by the collaborative and interdisciplinary NIH intramural program and state-of-the-art proteomics, high-throughput sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse transgenic, and other core facilities.
Job description : The laboratory is focused on using biochemical methods to study the assembly and functions of viral and cellular messenger ribonucleoprotein complexes. A major tool in these efforts is a novel system for RNA hairpin tag-based affinity purification of messenger ribonucleoproteins from human cells followed by mass spectrometry. This approach recently led to the identification of a mechanism by which the key NMD factor Upf1 is able to directly sense 3’UTR length in the process of decay target discrimination (see Hogg and Goff, Cell, 143, 379-89 for more details). The lab is now pursuing several projects designed to understand the mechanisms underlying 3’UTR length sensing by Upf1 and subversion of this process by retroviral RNA elements. These efforts require a combination of molecular, cell biological, biochemical, and proteomic techniques in mammalian cell culture and in vitro systems. More information is available at https://intramural.nhlbi.nih.gov/labs/LRB/Pages/default.aspx.

Salary : Salary is commensurate with research experience and accomplishments.
Educational Qualification : Interested candidates must have received a Ph.D. or M.D. within the past five years in molecular biology, cell biology, biochemistry, genetics or a related discipline and be highly motivated to participate in and design innovative research programs. The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.
To apply, send by email a cover letter describing research interests and career goals, a curriculum vitae, and contact information for least 3 references to : j.hogg@nih.gov by January 31, 2012
Deadline : 31.01.12